Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome

Abstract Background Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mutations.CcRCC is unusual for its high frequency of epigenetic regulator mutations, such as the SETD2 histone H3 lysine 36

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The Role of Fungi in the Etiology of Multiple Sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system.Infectious triggers of MS are being actively investigated.Substantial evidence supports the involvement of the Epstein-Barr Mains Block Insulator virus (EBV), though other viruses, bacteria, protists, and fungi are also being considered.Many links between fungi

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